Date of Award
Spring 5-18-2024
Document Type
Honors Project
University Scholars Director
Joshua Tom
First Advisor/Committee Member
Tracie Delgado
Keywords
Virus, Cancer, Drug, Treatment
Abstract
Viruses, including herpesviruses, contribute up to 15% of all human cancers. Murine gammaherpesvirus-68 (MHV-68), a pathogen commonly found in mice, is studied due to its shared homology with several human herpesviruses. Studies done in the Delgado lab via metabolomics analysis show MHV-68 infected cells increase host cell metabolism. Clinically relevant metabolic inhibitor drugs, ɑ-Difluoromethylornithine (DFMO) and Orlistat, respectively block polyamine and lipid production demonstrated a reduction in MHV-68 viral production. Repurposing clinically relevant drugs through the exploration of a different target shows great promise in reducing oncogenic viral titer.
Recommended Citation
Paw, Lay, "Repurposing Clinically Relevant Metabolic Inhibitor Drugs, Difluoromethylornithine (DFMO) and Orlistat, for gammaherpesvirus Replication" (2024). Honors Projects. 219.
https://digitalcommons.spu.edu/honorsprojects/219
Copyright Status
http://rightsstatements.org/vocab/InC/1.0/
Additional Rights Information
Copyright held by author.
Included in
Lipids Commons, Nucleic Acids, Nucleotides, and Nucleosides Commons, Other Chemicals and Drugs Commons, Virus Diseases Commons
