Date of Award
Spring 6-4-2025
Document Type
Honors Project
University Scholars Director
Dr. Joshua Tom
First Advisor/Committee Member
Dr. John Douglass
Keywords
glucose tolerance, TNF, obesity, type 2 diabetes, hypothalamus, inflammation
Abstract
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by impaired blood glucose regulation and persistent hyperglycemia. The central nervous system functions as a key regulator in the maintenance of peripheral normoglycemia. Obesity, commonly associated with T2DM, often leads to chronic inflammation in the hypothalamus, a critical brain center for integrating metabolic feedback and controlling outputs to peripheral organs. However, the physiological mechanisms through which obesity-induced brain inflammation affects glucose regulation remain somewhat unclear. Previous studies have linked one key pro-inflammatory cytokine, tumor necrosis factor alpha (TNF-α), to metabolic function and glycemic control; however, the exact nature of its impacts on glucose homeostasis remains ambiguous. This study aims to further explore the role of hypothalamic TNF-α in glucose regulation using an obese rodent model.
Recommended Citation
Griepp, Gabriela, "Effects of cerebral tumor necrosis factor alpha on systemic glucose homeostasis in obese mice" (2025). Honors Projects. 243.
https://digitalcommons.spu.edu/honorsprojects/243
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