Date of Award
Spring 6-6-2025
Document Type
Honors Project
University Scholars Director
Dr. Joshua Tom
First Advisor/Committee Member
Dr. Wade Grabow
Keywords
RNA, Biochemistry, Chemistry, Organic, nucleic acid, physical science
Abstract
An anion detecting luminescent probe, Tb:DO2A-Cs124, was repurposed for use in RNA imaging. Potential RNA aptamers were identified for the molecule using Capture-SELEX and MinION sequencing. Fluorimetry data revealed these aptamers did not allow for the probe to luminesce in the presence of target RNAs due to adenosine monophosphate’s ability to quench the emission signal.
Recommended Citation
Savell, Jonathan, "Lighting up the Cell: Developing a Luminescent Lanthanide Probe for Detecting RNAs" (2025). Honors Projects. 249.
https://digitalcommons.spu.edu/honorsprojects/249
Copyright Status
http://rightsstatements.org/vocab/InC/1.0/
Additional Rights Information
Copyright held by author.
