Date of Award
Spring 6-10-2022
Document Type
Honors Project
University Scholars Director
Christine Chaney
First Advisor/Committee Member
Ben McFarland
Keywords
FOXF2
Abstract
FOXF2 is a transcription factor that plays a crucial role in organ development, and recent studies have shown that it suppresses tumor growth and progression in mouse prostate models by attenuating the cancer-associated fibroblasts (CAF) phenotype and transcriptionally downregulating Cxcl5. However, the effects of FOXF2 overexpression in prostate cancer cells have not been extensively studied. Here, we investigate the impact of FOXF2 overexpression in prostate cancer cells and demonstrate that it leads to a significant increase in cell apoptosis and a decrease in proliferation. These findings suggest that FOXF2 may have potential as an immunotherapy drug target for prostate cancer treatment.
Recommended Citation
Poon, Vaughn, "Overexpression of FOXF2 in prostate cancer cells causes an increase in cancer cell apoptosis and a decrease in proliferation" (2022). Honors Projects. 199.
https://digitalcommons.spu.edu/honorsprojects/199
Copyright Status
http://rightsstatements.org/vocab/InC/1.0/
Additional Rights Information
Copyright held by author.
