Project Type
Research in progress
Primary Department
Psychology
Description
In this study, we are investigating the relationship between NMDA receptor antagonists and decision-making. Rats choose between a Fixed-Delay (FD) lever that dispensed a sugar pellet in ten-second intervals and a Progressive-Delay (PD) lever that dispensed a sugar pellet at progressively increasing time intervals of one second. After training on the optimal decision-making task, rats were injected with MK-801 in a randomized sequence of doses of 0.06 mL/g, 0.1 mL/ 0.2mL/g with saline as the control. Analysis of behaviors in relation to optimal choices is ongoing in relation to the varying doses of MK-801.
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Included in
Effects of NMDA inhibition of rodent decision-making and reward-seeking behavior
In this study, we are investigating the relationship between NMDA receptor antagonists and decision-making. Rats choose between a Fixed-Delay (FD) lever that dispensed a sugar pellet in ten-second intervals and a Progressive-Delay (PD) lever that dispensed a sugar pellet at progressively increasing time intervals of one second. After training on the optimal decision-making task, rats were injected with MK-801 in a randomized sequence of doses of 0.06 mL/g, 0.1 mL/ 0.2mL/g with saline as the control. Analysis of behaviors in relation to optimal choices is ongoing in relation to the varying doses of MK-801.
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