Analyzing drug-affected optimal performance of rats using generalized linear mixed models
Presentation Type
Event
Project Type
Research in progress
Primary Department
Psychology
Description
NMDA receptor antagonists are increasingly being researched for treating mood disorders, but there is much to learn about their cognitive effects. MK-801 has had varying effects on rodent decision-making. In this study, Sprague Dawley rats were injected with doses of MK-801 and saline before completing a task where lever presses returned fixed or progressively delayed rewards. Rats obtained more rewards by making optimal decisions considering the accumulated delays. By measuring optimal performance, we are further investigating the role of NMDA receptors in decision-making. Results of drug effects and optimal performance are currently being analyzed using generalized linear mixed models.
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Analyzing drug-affected optimal performance of rats using generalized linear mixed models
NMDA receptor antagonists are increasingly being researched for treating mood disorders, but there is much to learn about their cognitive effects. MK-801 has had varying effects on rodent decision-making. In this study, Sprague Dawley rats were injected with doses of MK-801 and saline before completing a task where lever presses returned fixed or progressively delayed rewards. Rats obtained more rewards by making optimal decisions considering the accumulated delays. By measuring optimal performance, we are further investigating the role of NMDA receptors in decision-making. Results of drug effects and optimal performance are currently being analyzed using generalized linear mixed models.
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