Sex-Specific neuroinflammatory effects of chronic social isolation and hyper-palatable diet in adolescent rodents

Faculty Sponsor(s)

Philip Baker, Ph.D.,Jessica Fossum, Ph.D.

Presentation Type

Presentation

Project Type

Research in progress

Primary Department

Psychology

Location

the Cascade Room in Upper Gwinn

Description

Literature has supported the impact of both social isolation and exposure to high fat-high sugar (“hyperpalatable”) diets on neuroinflammation and behavior in rats. Historically, these behavioral impacts are shown to differ between the sexes. This ongoing research project seeks to examine the relationship between these variables during peri-adolescence and adult neuroinflammatory responses within brain regions associated with cognition, memory, and behavior. Utilizing immunohistochemical staining of microglia, this study proposes that male and female rats will exhibit key differences in neuroinflammatory response to peri-adolescent stress and hyperpalatable diet.

Copyright Status

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Sex-Specific neuroinflammatory effects of chronic social isolation and hyper-palatable diet in adolescent rodents

the Cascade Room in Upper Gwinn

Literature has supported the impact of both social isolation and exposure to high fat-high sugar (“hyperpalatable”) diets on neuroinflammation and behavior in rats. Historically, these behavioral impacts are shown to differ between the sexes. This ongoing research project seeks to examine the relationship between these variables during peri-adolescence and adult neuroinflammatory responses within brain regions associated with cognition, memory, and behavior. Utilizing immunohistochemical staining of microglia, this study proposes that male and female rats will exhibit key differences in neuroinflammatory response to peri-adolescent stress and hyperpalatable diet.

Rights Statement

In Copyright